Selective Role for Mek1 but not Mek2 in the Induction of Epidermal NeoplasiaSCHOLL, Florence A; DUMESIC, Phillip A; BARRAGAN, Deborah I et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 9, pp 3772-3778, issn 0008-5472, 7 p.Article

Arabidopsis Mitogen-Activated Protein Kinase Kinases MKK1 and MKK2 Have Overlapping Functions in Defense Signaling Mediated by MEKK1, MPK4, and MKS1QIU, Jin-Long; LU ZHOU; YUN, Byung-Wook et al.Plant physiology (Bethesda). 2008, Vol 148, Num 1, pp 212-222, issn 0032-0889, 11 p.Article

Characterization of a Novel Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor with a Unique Mechanism of Action for Cancer TherapyDAOUTI, Sherif; HUISHENG WANG; QING XIANG et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 5, pp 1924-1932, issn 0008-5472, 9 p.Article

Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced CancersADJEI, Alex A; COHEN, Roger B; MALONEY, Lara et al.Journal of clinical oncology. 2008, Vol 26, Num 13, pp 2139-2146, issn 0732-183X, 8 p.Article

Characterization of CpSte11, a MAPKKK gene of Cryphonectria parasitica, and initial evidence of its involvement in the pheromone response pathwayPARK, Jin-Ah; KIM, Jung-Mi; PARK, Seung-Moon et al.Molecular plant pathology. 2012, Vol 13, Num 3, pp 240-250, issn 1464-6722, 11 p.Article

A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignanciesCOHEN, Roger B; AAMDAL, Steinar; NYAKAS, Marta et al.European journal of cancer (1990). 2013, Vol 49, Num 7, pp 1521-1529, issn 0959-8049, 9 p.Article

ZmMKK3, a novel maize group B mitogen-activated protein kinase kinase gene, mediates osmotic stress and ABA signal responsesMAOYING ZHANG; JIAOWEN PAN; XIANGPEI KONG et al.Journal of plant physiology. 2012, Vol 169, Num 15, pp 1501-1510, issn 0176-1617, 10 p.Article

Suppression of MAPKAPK2 during mammalian hibernationABNOUS, Khalil; DIENI, Christopher A; STOREY, Kenneth B et al.Cryobiology (Print). 2012, Vol 65, Num 3, pp 235-241, issn 0011-2240, 7 p.Article

Two mitogen-activated protein kinase kinases, MKK1 and MEK2, are involved in wounding- and specialist lepidopteran herbivore Manduca sexta-induced responses in Nicotiana attenuataHEINRICH, Maria; BALDWIN, Ian T; JIANQIANG WU et al.Journal of experimental botany. 2011, Vol 62, Num 12, pp 4355-4365, issn 0022-0957, 11 p.Article

Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancerMIN JIA; SOUCHELNYTSKYI, Nazariy; HELLMAN, Ulf et al.Proteomics. Clinical applications (Print). 2010, Vol 4, Num 10-11, pp 816-828, issn 1862-8346, 13 p.Article

Mélanome = MelanomaMORTIER, L.La Lettre du cancérologue (Boulogne). 2013, Vol 22, Num 7, issn 1165-113X, 315-323 [8 p.]Article

ZmMKK4, a novel group C mitogen-activated protein kinase kinase in maize (Zea mays), confers salt and cold tolerance in transgenic ArabidopsisXIANGPEI KONG; JIAOWEN PAN; MAOYING ZHANG et al.Plant, cell and environment (Print). 2011, Vol 34, Num 8, pp 1291-1303, issn 0140-7791, 13 p.Article

Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With Metastatic BRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF InhibitorKIM, Kevin B; KEFFORD, Richard; GONZALEZ, Rene et al.Journal of clinical oncology. 2013, Vol 31, Num 4, pp 482-489, issn 0732-183X, 8 p.Article

The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatmentHAAGENSON, Kelly K; GEN SHENG WU.Cancer metastasis reviews. 2010, Vol 29, Num 1, pp 143-149, issn 0167-7659, 7 p.Article

Selective Growth Inhibition in BEAT Mutant Thyroid Cancer by the Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244BALL, Douglas W; NING JIN; ROSEN, D. Marc et al.The Journal of clinical endocrinology and metabolism. 2007, Vol 92, Num 12, pp 4712-4718, issn 0021-972X, 7 p.Article

Discovery of MEK/PI3K dual inhibitor via structure-based virtual screeningPARK, Hwangseo; LEE, Soyoung; HONG, Sungwoo et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 15, pp 4946-4950, issn 0960-894X, 5 p.Article

Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cellsMARTINELLI, Erika; TROIANI, Teresa; DE VRIENDT, Veerle et al.International journal of cancer (Print). 2013, Vol 133, Num 9, pp 2089-2101, issn 0020-7136, 13 p.Article

Oxindole derivatives as inhibitors of TAK1 kinaseLOCKMAN, Jeffrey W; REEDER, Matthew D; ROBINSON, Rosann et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 6, pp 1724-1727, issn 0960-894X, 4 p.Article

La voie des mitogen actived protein kinases (MAPK), cible de stratégies antitumorales = The mitogen actived protein kinases (MAPK) pathway, a target for anticancer drugsFAVRE, Gilles.Bulletin du cancer. 2006, Num AVR, pp 25-30, issn 0007-4551, 6 p., HSArticle

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive RasLAUCHLE, Jennifer O; KIM, Doris; DIAZ-FLORES, Ernesto et al.Nature (London). 2009, Vol 461, Num 7262, pp 411-414, issn 0028-0836, 4 p.Article

MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylationSUN, Bo K; KIM, Joo-Hang; NGUYEN, Hoan N et al.Oncology reports. 2011, Vol 25, Num 2, pp 537-544, issn 1021-335X, 8 p.Article

Role of mitogen-activated protein kinase kinase kinases in signal integrationCUEVAS, B. D; ABELL, A. N; JOHNSON, G. L et al.Oncogene (Basingstoke). 2007, Vol 26, Num 22, pp 3159-3171, issn 0950-9232, 13 p.Article

Stomatal development and pattern controlled by a MAPKK kinaseBERGMANN, Dominique C; LUKOWITZ, Wolfgang; SOMERVILLE, Chris R et al.Science (Washington, D.C.). 2004, Vol 304, Num 5676, pp 1494-1497, issn 0036-8075, 4 p.Article

Independent human MAP kinse signal transduction pathways defined by MEK and MKK isoformsDERIJARD, B; RAINGEAUD, J; BARRETT, T et al.Science (Washington, D.C.). 1995, Vol 267, Num 5198, pp 682-685, issn 0036-8075Article

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2JIE WU; HARRISON, J. K; DENT, P et al.Molecular and cellular biology (Print). 1993, Vol 13, Num 8, pp 4539-4548, issn 0270-7306Article